The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping
Summary: Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and -propagating population remarkably vulnerable to variation in the stability and integrity of the lysosomal compartment.Previous work has shown that the expression and activity of the paracaspase MALT1 control GSC viability via lysosome abundance.However, the underlying mech