THE PARACASPASE MALT1 CONTROLS CHOLESTEROL HOMEOSTASIS IN GLIOBLASTOMA STEM-LIKE CELLS THROUGH LYSOSOME PROTEOME SHAPING

The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping

Summary: Glioblastoma stem-like cells (GSCs) compose a tumor-initiating and -propagating population remarkably vulnerable to variation in the stability and integrity of the lysosomal compartment.Previous work has shown that the expression and activity of the paracaspase MALT1 control GSC viability via lysosome abundance.However, the underlying mech

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The Replacement of Criminal Fine in Criminal Taxation

The absence of provisions regulating the substitution of criminal fines in the KUP Law, raises legal uncertainty for law enforcement officials, especially prosecutors in executing court decisions.Considering the recovery of state financial losses that Fever can be resolved by the consistency of court decisions, so the provisions in the KUP Law must

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An atypical presentation of metastatic Ewing sarcoma to the spine

Ewing sarcoma (ES) is a rare malignancy of the young, primarily arising from the bones.Uncommonly, it can arise extraskeletally and, among the rarest cases, from the spinal extradural tissues.The patient is a previously well 26-year-old male who presented with radicular Hair Coloring low back pain.Magnetic resonance imaging revealed an L5-S1 spinal

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